Abstract
In addition to the modification of the lipid profile, most lipid-lowering agents appear to modulate other atherogenic pathways. We summarize the effects of lipid-lowering agents on inflammation, hemostasis and blood pressure. We also discuss the potential contribution of these actions on cardiovascular disease prevention. Most lipid-lowering agents appear to exert anti-inflammatory, antithrombotic and antihypertensive effects. These pleiotropic actions appear to contribute to the reduction in cardiovascular events and deep venous thrombosis during statin treatment. Regarding other lipid-lowering agents, it is unclear whether their effects on inflammation, thrombosis or blood pressure play a role in their antiatherogenic potential.
Keywords: Statins, fibrates, ezetimibe, colesevelam, nicotinic acid, C-reactive protein, fibrinogen, blood pressure, pleiotropic effects.
Current Pharmaceutical Design
Title:Effects of Lipid-Lowering Agents on Inflammation, Haemostasis and Blood Pressure
Volume: 20 Issue: 40
Author(s): Konstantinos Tziomalos, Asterios Karagiannis and Vasilios G. Athyros
Affiliation:
Keywords: Statins, fibrates, ezetimibe, colesevelam, nicotinic acid, C-reactive protein, fibrinogen, blood pressure, pleiotropic effects.
Abstract: In addition to the modification of the lipid profile, most lipid-lowering agents appear to modulate other atherogenic pathways. We summarize the effects of lipid-lowering agents on inflammation, hemostasis and blood pressure. We also discuss the potential contribution of these actions on cardiovascular disease prevention. Most lipid-lowering agents appear to exert anti-inflammatory, antithrombotic and antihypertensive effects. These pleiotropic actions appear to contribute to the reduction in cardiovascular events and deep venous thrombosis during statin treatment. Regarding other lipid-lowering agents, it is unclear whether their effects on inflammation, thrombosis or blood pressure play a role in their antiatherogenic potential.
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Cite this article as:
Tziomalos Konstantinos, Karagiannis Asterios and Athyros G. Vasilios, Effects of Lipid-Lowering Agents on Inflammation, Haemostasis and Blood Pressure, Current Pharmaceutical Design 2014; 20 (40) . https://dx.doi.org/10.2174/1381612820666140622201452
DOI https://dx.doi.org/10.2174/1381612820666140622201452 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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