The concentration of low-density lipoprotein cholesterol has long been generally accepted as one of the strongest, independent
risk factors for the development of cardiovascular disease. However, an increasing number of studies suggest that the ratio of apolipoprotein
B (apoB) to apolipoprotein A-I (apoA-I) is a better risk predictor. In the present review, we focus on apoB and apoA-I as factors in
predicting vascular risk in epidemiological studies only, and not in studies involving pharmaceutical intervention. The majority of studies
in the present review show that apoB and the apoB/apoA-I ratio are independently and more strongly associated with vascular risk across
varying age-groups and geographic regions than are conventional lipids, lipoproteins and lipid ratios.
Keywords: Apolipoprotein B, apoB/apoA-I ratio, intima-media thickness, plaque, myocardial infarction, stroke, peripheral atherosclerosis.
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