Cell-Penetrating Peptide-Mediated Topical Delivery of Biomacromolecular Drugs

Author(s): Jiao Tan, Heesun Cheong, Yoon Shin Park, Hangun Kim, Meng Zhang, Cheol Moon, Yongzhuo Huang

Journal Name: Current Pharmaceutical Biotechnology

Volume 15 , Issue 3 , 2014

Become EABM
Become Reviewer
Call for Editor


Biomacromolecules play an important role in the treatment of many diseases, but their topical application has been limited by their poor cell membrane permeability. Cell-penetrating peptides (CPPs) have been investigated over the past few decades as a potential strategy to overcome this challenge. CPPs can effectively mediate the cellular uptake of poorly internalized biomacromolecules without unfavorable side effects and have therefore attracted considerable interest as a viable alternative to existing parenteral therapies involving biomacromolecules. In this review, we will highlight the application of CPPs to the non-invasive delivery of biomacromolecules, with a focus on percutaneous and nasal absorption of biomacromolecules administered using CPPs.

Keywords: Biomacromolecules, cell-penetrating peptide, intranasal delivery, non-invasive delivery, percutaneous delivery, topical administration.

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2014
Published on: 21 August, 2014
Page: [231 - 239]
Pages: 9
DOI: 10.2174/1389201015666140617094320
Price: $65

Article Metrics

PDF: 65