Facile Synthesis of Novel N4-Substituted 2-(Trifluoromethyl)-tetrahydrobenzothieno[ 2,3-d]pyrimidine Derivatives

Author(s): Fasong Wang, Hui Gao, Ping Yang, Yan Wang, Xinjian Song.

Journal Name: Letters in Organic Chemistry

Volume 11 , Issue 9 , 2014

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Graphical Abstract:


A series of novel N4-substituted 2-(trifluoromethyl)-tetrahydrobenzothieno[2,3-d]pyrimidine derivatives were synthesized by a facile three-step procedure that presented such advantages as easily accessible starting materials, mild reaction conditions, simple protocol and good overall yields. The structures of the title compounds were confirmed by IR, 1H NMR, 13C NMR, EI-MS, elemental analysis, and single-crystal X-ray diffraction.

Keywords: Facile synthesis, crystal structure, Gewald reaction, thieno[2, 3-d]pyrimidines, fluorinated compounds.

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Article Details

Year: 2014
Page: [700 - 705]
Pages: 6
DOI: 10.2174/1570178611666140609225422
Price: $65

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