Non-Cross-Linked Polystyrene Supported Cyclosulfamide as a New Chiral Auxiliary for Asymmetric Aldol Reactions

Author(s): Taotao Lu, Cuifen Lu, Junqi Nie, Zuxing Chen, Guichun Yang

Journal Name: Current Organic Synthesis

Volume 12 , Issue 1 , 2015


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Abstract:

The synthesis of a new non-cross-linked polystyrene supported cyclosulfamide chiral auxiliary is described. Asymmetric aldol reactions using this auxiliary proceeded with good yields and excellent stereoselectivities, which were comparable with those observed by using non-supported cyclosulfamide chiral auxiliary. Furthermore, recovery and recycling of this polymer supported chiral auxiliary have been successfully achieved without appreciable reduction in the yield or stereoselectivity.

Keywords: Asymmetric aldol reactions, chiral auxiliary, cyclosulfamide, non-cross-linked polystyrene, supported.

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Article Details

VOLUME: 12
ISSUE: 1
Year: 2015
Page: [61 - 66]
Pages: 6
DOI: 10.2174/1570179411666140530211735

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