This paper reviews puerperal metritis in the cow, particularly the complex and multi-factorial pathogenesis
characterized by an altered cross-talk among infectious agents, endocrine and immune systems. Uterine infections impair
fertility and is one of the main causes of economic losses in dairy production. The early postpartum is a period
characterized by an increased exposition to infectious agents and the disruption of the metabolic homeostasis, leading to
endocrine and immunologic disorders. Dysregulation of uterine defence mechanisms results in the development of
metritis. Because there is a complex interaction between infectious, endocrine and immune factors during metritis, there is
need to use safer and cheaper drugs which are able to strengthen the anti-infective actions of the routine therapies.
Keywords: Dairy cow, immunity, metritis, postpartum, uterine, uterus inflammatory diseases.
Rights & PermissionsPrintExport