The standard gold care medications for benign prostatic hyperplasia (BPH) are the alpha-1-adrenergic
antagonists, they are an effective medications and are generally well tolerated. However, at this time, no data have been
published concerning the development of severe rhinorrhea with a great impact on quality of life in patients treated with
alpha-1-adrenergic antagonists. We report two men with BPH treated with two different alpha-adrenergic antagonists;
alfuzosin and doxazocin. The naranjo quality scale documented a probable adverse drug reaction (score 7) between
rhinorrhea and treatmenr with alpha-1-adrenergic antagonists. In conclusion we reported that alpha-1-adrenergic
antagonists are able to induce rhinorrhea in patients with BPH.