Bacteriocins Active Against Multi-Resistant Gram Negative Bacteria Implicated in Nosocomial Infections

Author(s): Hanen Ghodhbane, Sabrine Elaidi, Jean-Marc Sabatier, Sami Achour, Jeannette Benhmida, Imed Regaya

Journal Name: Infectious Disorders - Drug Targets
Formerly Current Drug Targets - Infectious Disorders

Volume 15 , Issue 1 , 2015

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Multiresistant Gram-negative bacteria are the prime mover of nosocomial infections. Some are naturally resistant to antibiotics, their genetic makes them insensitive to certain families of antibiotics and they transmit these resistors to their offspring. Moreover, when bacteria are subjected to antibiotics, they eventually develop resistance against drugs to which they were previously sensitive. In recent years, many bacteriocins active against gram-negative bacteria have been identified proving their efficacy in treating infections. While further investigation remains necessary before the possibilities for bacteriocins in clinical practice can be described more fully, this review provides an overview of bacteriocins acting on the most common infectious gram negative bacteria (Klebsiella, Acinetobacter, Pseudomonas aeruginosa and E. coli).

Keywords: Bacteriocins, Enterobacteriacae, gram negative bacteria, nosocomial infections.

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Article Details

Year: 2015
Published on: 21 April, 2015
Page: [2 - 12]
Pages: 11
DOI: 10.2174/1871526514666140522113337

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