Multiresistant Gram-negative bacteria are the prime mover of nosocomial infections. Some
are naturally resistant to antibiotics, their genetic makes them insensitive to certain families of antibiotics
and they transmit these resistors to their offspring. Moreover, when bacteria are subjected to antibiotics, they eventually
develop resistance against drugs to which they were previously sensitive. In recent years, many bacteriocins active
against gram-negative bacteria have been identified proving their efficacy in treating infections. While further investigation
remains necessary before the possibilities for bacteriocins in clinical practice can be described more fully, this review
provides an overview of bacteriocins acting on the most common infectious gram negative bacteria (Klebsiella, Acinetobacter,
Pseudomonas aeruginosa and E. coli).