Abstract
Quercetin, a natural protective bioflavonoid, possesses diverse pharmacologic effects, such as antioxidant, anti-inflammatory, anti-proliferative, and anti-angiogenic activities. Recently, quercetin’s effect in cancer prevention and treatment was recognized. However, the poor water solubility and low-bioavailability of quercetin limit its clinical use in cancer therapy. Nanotechnology provides a method to create novel formulations for hydrophobic drug. Nanoparticles-delivered quercetin has attracted many attentions for its enhanced anticancer potential and promising clinical application. This review will discuss the application of nanotechnology in quercetin delivery for cancer therapy.
Keywords: Cancer therapy, nanoparticle, nanotechnology, quercetin.
Anti-Cancer Agents in Medicinal Chemistry
Title:Nanoparticle-Delivered Quercetin for Cancer Therapy
Volume: 14 Issue: 6
Author(s): Ke Men, Xingmei Duan, Xia Wei Wei, Ma Ling Gou, Mei Juan Huang, Li Juan Chen, Zhi Yong Qian and Yu Quan Wei
Affiliation:
Keywords: Cancer therapy, nanoparticle, nanotechnology, quercetin.
Abstract: Quercetin, a natural protective bioflavonoid, possesses diverse pharmacologic effects, such as antioxidant, anti-inflammatory, anti-proliferative, and anti-angiogenic activities. Recently, quercetin’s effect in cancer prevention and treatment was recognized. However, the poor water solubility and low-bioavailability of quercetin limit its clinical use in cancer therapy. Nanotechnology provides a method to create novel formulations for hydrophobic drug. Nanoparticles-delivered quercetin has attracted many attentions for its enhanced anticancer potential and promising clinical application. This review will discuss the application of nanotechnology in quercetin delivery for cancer therapy.
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Cite this article as:
Men Ke, Duan Xingmei, Wei Wei Xia, Gou Ling Ma, Huang Juan Mei, Chen Juan Li, Qian Yong Zhi and Wei Quan Yu, Nanoparticle-Delivered Quercetin for Cancer Therapy, Anti-Cancer Agents in Medicinal Chemistry 2014; 14 (6) . https://dx.doi.org/10.2174/1871520614666140521122932
DOI https://dx.doi.org/10.2174/1871520614666140521122932 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
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