Long-term Treatment of Venous Thromboembolism

Author(s): Cecilia Becattini, Giorgia Manina

Journal Name: Current Vascular Pharmacology

Volume 12 , Issue 3 , 2014

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Long term treatment of venous thromboembolism is essential to complete therapy of the index episode and to reduce recurrences. Vitamin K antagonists are the mainstay for the long term treatment of venous thromboembolism for the majority of the patients as they allow oral administration. Low-molecular weight heparins are recommended for the long term treatment of cancer patients. The duration of long term anticoagulation depends on the features of the index venous thromboembolism and on the presence of associated risk factors. Patients at high risk for recurrence – mainly those who suffered unprovoked venous thromboembolism and those with cancer – should be evaluated for extended anticoagulation. The risk for major bleeding complications and the inconvenience for monitoring, dose adjustment and drug-food interactions are the main constraints for indefinite anticoagulant treatment. New anticoagulants with more favourable efficacy- safety profile and reduced need for monitoring could improve the feasibility of extended anticoagulation.

Keywords: Venous thromboembolism, vein thrombosis, pulmonary embolism, anticoagulants.

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Article Details

Year: 2014
Page: [384 - 392]
Pages: 9
DOI: 10.2174/157016111203140518154040
Price: $65

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PDF: 27