Application of chemometric methods in the study of the retention indices of thirteen 5-arylidene-2,4-
thiazolidinediones in two low polarity high-performance thin-layer chromatographic (HPTLC) stationary phases (RP-18
and RP-CN) and six aqueous mobile phases. Principal component analysis classified chromatographic systems into four
specific groups while one system remained non-classified. Hierarchical clustering analysis enabled grouping of the
chromatographic systems into three clusters, and the studied compounds into three main classes. The color map enabled
more in-depth interpretation of the relationships between the studied compounds and HPTLC systems applied.
Keywords: 5-arylidene-2, 4-thiazolidinediones, classification, color map, dendrogram, HCA, PCA.
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