The increasing resistance of microorganisms against antibiotics available on the pharmaceutical market is now
a global problem. There is an incessant necessity to search for new, effective treatments against resistant strains of
microorganisms, for new potent classes of antibiotics with novel modes of action targeted at important components of
microbial cells. Such a critical, essential system for cell functioning is a RNA polymerase (RNAP), an enzyme that
catalyses one of the stages of gene expression: transcription. RNAP is a proven target for a number of antibiotics, and it
still remains an attractive drug target for new potent antimicrobial compounds. In this review several examples of
inhibitors for transcription and RNAP are presented.