Abstract
A series of twelve pyrralothiazoles was synthesized using [3+2]- cycloaddition reactions. The synthesized compounds were screened for their antimycobacterial activity against M. tuberculosis H37Rv and INH resistant M. tuberculosis strains using agar dilution method, four of them showed good activity with MIC of less than 1µM. Compound (4d) was found to be the most active with MIC of 0.231 µM and 4.372 µM respectively.
Keywords: [3+2]-cycloaddition, Antimycobacterial activity, Azomethine ylide, Dispiroheterocycle, Intermolecular.
Letters in Drug Design & Discovery
Title:Synthesis and Antimycobacterial Activity of Highly Functionalised Pyrrolothiazole Derivatives
Volume: 11 Issue: 8
Author(s): Abdulrahman I. Almansour, Venu Sanjeevi Lakshmipathi, Elumalai Manogaran, Mohamed Ashraf Ali, Farzana Beevi, Tan Soo Choon, Ang Chee Wei, Raju Suresh Kumar and Mohammad Asad
Affiliation:
Keywords: [3+2]-cycloaddition, Antimycobacterial activity, Azomethine ylide, Dispiroheterocycle, Intermolecular.
Abstract: A series of twelve pyrralothiazoles was synthesized using [3+2]- cycloaddition reactions. The synthesized compounds were screened for their antimycobacterial activity against M. tuberculosis H37Rv and INH resistant M. tuberculosis strains using agar dilution method, four of them showed good activity with MIC of less than 1µM. Compound (4d) was found to be the most active with MIC of 0.231 µM and 4.372 µM respectively.
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Almansour I. Abdulrahman, Lakshmipathi Sanjeevi Venu, Manogaran Elumalai, Ali Ashraf Mohamed, Beevi Farzana, Choon Soo Tan, Wei Chee Ang, Kumar Suresh Raju and Asad Mohammad, Synthesis and Antimycobacterial Activity of Highly Functionalised Pyrrolothiazole Derivatives, Letters in Drug Design & Discovery 2014; 11 (8) . https://dx.doi.org/10.2174/1570180811666140506204239
DOI https://dx.doi.org/10.2174/1570180811666140506204239 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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