Enantioselective Synthesis of PPAR (Peroxisome Proliferator-Activated Receptors) Agonists and Antagonists

Author(s): Pilar Goya, Ruth Perez-Fernandez, Rosario Gonzalez-Muniz, Jose Elguero

Journal Name: Current Topics in Medicinal Chemistry

Volume 14 , Issue 10 , 2014

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Graphical Abstract:


This review deals with stereoselective issues in PPAR ligands some of which are in clinical use for treating certain metabolic disorders. After a short introduction of these nuclear receptor and their agonists, some cases of enantioselective separations are reported. The main part concerns stereoselective synthesis first starting with asymmetric synthesis from chiral precursors followed by what we refer to as “true” enantioselective methods. Some examples are discussed in detail for each particular heading.

Keywords: PPAR, enantioselective separation, enantioselective synthesis, Evans' chiral auxiliary, asymmetric hydrogenation, chiral HPLC, chiral salts.

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Article Details

Year: 2014
Published on: 16 May, 2014
Page: [1283 - 1293]
Pages: 11
DOI: 10.2174/1568026614666140423112822
Price: $65

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