Enantioselective Synthesis in Carbohydrate-Based Drug Discovery: Imino Sugars, Alkaloids and Macrolide Antibiotics

Author(s): Nuno M. Xavier, Amélia P. Rauter

Journal Name: Current Topics in Medicinal Chemistry

Volume 14 , Issue 10 , 2014

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Graphical Abstract:


This review is dedicated to enantioselective methods for the generation of carbohydrate-based lead compounds for drug research. Selected examples encompassing imino sugars, bicyclic imino sugar-type alkaloids such as castanospermine, swainsonine, or alexine, as well as macrolide glycosides are covered and discussed.

Keywords: Alkaloids, carbohydrates, enantioselective synthesis, imino sugars, macrolide glycosides.

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Article Details

Year: 2014
Published on: 16 May, 2014
Page: [1235 - 1243]
Pages: 9
DOI: 10.2174/1568026614666140423103848
Price: $65

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