Synthesis of 4-oxo-2,5-cyclopentadiene Using Multi-component Reactions of Primary Amines and Electron Deficient Acetylenic Compounds with Triphenylphosphine in Water

Author(s): Samereh Seyfi, Faramarz Rostami-Charati, Zinatossadat Hossaini, Mohammad R. Zardoost

Journal Name: Letters in Organic Chemistry

Volume 11 , Issue 6 , 2014

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Graphical Abstract:


A water-accelerated multicomponent synthesis of organic target molecules has been used as a key method for the preparation of cyclopentadiene derivatives. The three-component condensation reactions of primary amines with alkyl propiolates in the presence of triphenylphosphine in water at 80 °C are developed as efficient and clean green synthetic procedures for the high-yielding preparation of 4-oxo-2,5-cyclopentadiene-1,2-dicarboxylate derivatives.

Keywords: Cyclopentadiene, primary amines, triphenylphosphine, alkyl propiolates, multi-component reaction.

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Article Details

Year: 2014
Published on: 13 April, 2014
Page: [409 - 412]
Pages: 4
DOI: 10.2174/157017861106140413171933
Price: $65

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