Treatments of obesity and type II diabetes target often gene functions involved in appetite-satiety, fat and carbohydrate
metabolism or thermogenesis. None of these, have provided efficient drug therapy due to a large number of
genes involved in weight and energy management, the redundancy of biochemical pathways and the environmental factors.
Here I discuss a new approach based on studies of genes/proteins that are associated with human “lean or starvation"
phenotype that became very rare in the course of evolution. This approach has led to the identification of the congenital
enteropeptidase deficiency gene and the Andersonʼs Disease gene as a potential targets for obesity and type II diabetes
treatment. The advantages of these targets are: 1) they are expressed exclusively in the intestine; 2) they are peripheral
targets as opposed to systemic targets; 3) they are not redundant targets. These targets open new hopes for the development
of novel drugs for the treatment of common metabolic syndrome.
Keywords: Diabetes treatment, drug discovery, lean phenotype, metabolic disorders, obesity, starvation phenotype, type II
Rights & PermissionsPrintExport