Neonatal brain injury remains a devastating condition, with poor outcomes despite the institution of an effective
neuroprotective strategy of therapeutic hypothermia. There is an urgent need to develop additional neuroprotective
strategies and to tailor our clinical predictive ability for families and their infants. Such goals could be more readily
achieved if reliable early clinical indicators or biomarkers existed. This review will explore the relation between magnetic
resonance (MR) imaging biomarkers and the degree of brain pathology observed in our translational piglet model of perinatal
asphyxia. We also suggest biomarker relevance at a cellular level. The review will describe the development needed
to optimize and simplify the use of biomarkers to speed up future trials of neuroprotection.
Keywords: Neonatal encephalopathy, magnetic resonance imaging, biomarkers, magnetic resonance spectroscopy, electroencephalography.
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