Title:Recent Developments on Thiourea Based Anticancer Chemotherapeutics
VOLUME: 15 ISSUE: 2
Author(s):Vikas Kumar and Swapandeep Singh Chimni
Affiliation:Department of Chemistry, U.G.C. Center of Advance Studies in Chemistry, Guru Nanak Dev University, Amritsar-143005, India.
Keywords:Anticancer chemotherapeutics, carbonic anhydrase (CA) inhibitors, protein tyrosine kinase inhibitors, sirtuins inhibitors, thiourea,
somatostatin agonists, topoisomerase inhibitors.
Abstract:The recent emergence of anticancer activity of thiourea derivatives have inspired the medicinal chemist to
design and synthesize new thiourea derivatives. These thiourea based anticancer chemotherapeutics inhibit cancer
propagation by acting as inhibitors of topoisomerase, protein tyrosine kinase, somatostatin agonists, sirtuins, and
carbonic anhydrase (CA). This review summarizes the recent developments on the thiourea based anticancer
chemotherapeutics.
