Spirocyclic scaffolds are embedded in many biologically active natural and synthetic compounds. Efforts have
been made time to time to develop new and better methodologies for the preparation of spirocyclic compounds. Noteworthy
advantages were observed during the course of our study on “in water” synthesis of spirocyclic compounds. The established
advantages of using water as a solvent in reactions are: water is the most abundant and available resource on the
planet and that many biochemical processes occur in aqueous medium. This review is focused on the use of water in the
synthesis of spirocyclic compounds.
Keywords: Heterocycles, spiro compounds, water, synthesis.
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