Snake Venom Proteins: Development into Antimicrobial and Wound Healing Agents

Title:Snake Venom Proteins: Development into Antimicrobial and Wound Healing Agents

Volume: 11 Issue: 1

Author(s): Ramar Perumal Samy, Jayapal Manikandan, Gautam Sethi, Octavio L. Franco, Josiah C. Okonkwo, Bradley G. Stiles, Vincent T.K. Chow, Ponnampalam Gopalakrishnakone and Mohammed Al Qahtani

Affiliation:

Keywords: Methicillin-resistant Staphylococcus aureus (MRSA), snake venom protein, endogenous antibiotics, Lys49 & Asp49-PLA₂, inflammatory cytokines, growth factors, skin, wound healing, transcription factors NF-kB, Cys-rich protein.

Abstract: Infectious diseases are a significant cause of morbidity and mortality worldwide, accounting for approximately 50% of all deaths in tropical countries and as much as 20% of deaths in the USA. The emergence of multi-drug resistant (MDR) strains makes the risk of these infections even more threatening and an important public health problem thereby increasing need of new agents for fighting pathogens. In this review, the remarkable antibacterial properties possessed by various snake venoms (Crotalide, Elapidae, and Viperidae families) were discussed and in particular phospholipase A₂s (PLA₂s) that have emerged from various studies as potential in the last few years. Group IIA PLA₂s are the most potent among the snake venom (sv)PLA₂s against various types of bacteria. Further, antibacterial derivatives from PLA₂s, e.g. peptides derived from the C-terminal sequence of Lys49-PLA₂s (amino acids 115-129), kill bacteria and cause severe membrane-damaging effects. Mechanisms of binding to the bacterial surface and subsequent killing by peptides are based on positive charge, hydrophobicity, and length. These peptide candidates are easy to design and synthesize in pure form (~95% purity). Such peptides may be potentially useful in the clinic as new antimicrobials for combating infections due to antibiotic-resistant bacteria that include methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus in the near future.

Cite this article as:

Samy Perumal Ramar, Manikandan Jayapal, Sethi Gautam, Franco L. Octavio, Okonkwo Josiah C., Stiles Bradley G., Chow Vincent T.K., Gopalakrishnakone Ponnampalam and Al Qahtani Mohammed, Snake Venom Proteins: Development into Antimicrobial and Wound Healing Agents, Mini-Reviews in Organic Chemistry 2014; 11 (1) . https://dx.doi.org/10.2174/1570193X1101140402100131