Title:Liposomes as Nanovaccine Delivery Systems
VOLUME: 14 ISSUE: 9
Author(s):Khairunnisa Abdul Ghaffar, Ashwini Kumar Giddam, Mehfuz Zaman, Mariusz Skwarczynski and Istvan Toth
Affiliation:School of Chemistry & Molecular Biosciences, University of Queensland, Chemistry Blg #68 St. Lucia, Queensland 4072, Australia.
Keywords:Administration route, bilosome, liposome, niosome, size-dependent immunity, vaccine delivery, virosome.
Abstract:Since the discovery of liposomes by Alec Bangham in mid-1960s, these phospholipid vesicles have been
widely used as pharmaceutical carriers. Liposomes have been extensively studied in the vaccine delivery field as a carrier
and an immune stimulating agent. Liposomes are usually formulated as nanoparticles, mimicking the properties of pathogens,
and have the ability to induce humoral and cell-mediated immune responses. In this review, we focused on modern
nanotechnology-based approaches for the improvement of liposomal vaccine delivery systems. Topics such as sizedependent
uptake, processing and activation of antigen presenting cells, targeting liposomes and route of administration
are discussed.
