Abstract
Organic chemists utilize azide synthons to generate a wide variety of functionalities, such as triazoles, tetrazoles, and diazo compounds. Though these products are often pharmacophores for biologically active molecules, the potentially hazardous nature of azides can act as a deterrent to their use in conventional reaction settings as they and diazo compounds are both explosive and toxic. Consequently, safer and greener methods of handling such reagents are needed and are being pursued. Among emerging methods are technology assisted syntheses by means of continuous flow processes, and processes where the compounds are generated in situ, eliminating the need for isolation. Additionally, new diazo-transfer agents have been developed that utilize polymer supports to minimize handling concerns. This mini-review will highlight recent advances in the field.
Keywords: Azide, click chemistry, continuous flow, diazo transfer, green chemistry, microreactor, triazole.
Current Organic Synthesis
Title:Safer, Greener, and More Facile Alternatives for Synthesis with Organic Azides
Volume: 11 Issue: 5
Author(s): Meaghan M. Sebeika and Graham B. Jones
Affiliation:
Keywords: Azide, click chemistry, continuous flow, diazo transfer, green chemistry, microreactor, triazole.
Abstract: Organic chemists utilize azide synthons to generate a wide variety of functionalities, such as triazoles, tetrazoles, and diazo compounds. Though these products are often pharmacophores for biologically active molecules, the potentially hazardous nature of azides can act as a deterrent to their use in conventional reaction settings as they and diazo compounds are both explosive and toxic. Consequently, safer and greener methods of handling such reagents are needed and are being pursued. Among emerging methods are technology assisted syntheses by means of continuous flow processes, and processes where the compounds are generated in situ, eliminating the need for isolation. Additionally, new diazo-transfer agents have been developed that utilize polymer supports to minimize handling concerns. This mini-review will highlight recent advances in the field.
Export Options
About this article
Cite this article as:
Sebeika M. Meaghan and Jones B. Graham, Safer, Greener, and More Facile Alternatives for Synthesis with Organic Azides, Current Organic Synthesis 2014; 11 (5) . https://dx.doi.org/10.2174/1570179411666140328221938
DOI https://dx.doi.org/10.2174/1570179411666140328221938 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
Call for Papers in Thematic Issues
Exploring the Role of Chemical Graph Theory in Advancing Current Organic Synthesis
Organic synthesis is a fundamental discipline in chemistry, crucial for the creation of complex molecules with diverse applications in pharmaceuticals, materials science, and beyond. However, the process of designing efficient synthetic routes for target molecules remains challenging. Chemical graph theory, a branch of theoretical chemistry, offers powerful tools for understanding ...read more
Photoswitches for Molecular Recognition
This Special Issue would cover the hot topics on synthesis and chemical and photophysical characterization of new photoswitchable derivatives and their applications on molecular recognition of metabolites and biological active compounds, both in physiological medium and in living cells. Photoswitches are compounds that can change their conformation or properties in ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Pharmacological Profile and Pharmacogenomics of Anti-Cancer Drugs Used for Targeted Therapy
Current Cancer Drug Targets Targeting Cytosolic Phospholipase A2α for Novel Anti-Inflammatory Agents
Current Medicinal Chemistry G Protein-Coupled Receptors in Regulation of Body Weight
CNS & Neurological Disorders - Drug Targets Drug Discovery and Protein Tyrosine Phosphatases
Current Medicinal Chemistry Multifunctionalized Microbubbles for Cancer Diagnosis and Therapy
Anti-Cancer Agents in Medicinal Chemistry Macrophage-Assisted Inflammation and Pharmacological Regulation of the Cholinergic Anti-Inflammatory Pathway
Current Medicinal Chemistry The Diversity of Epithelial Secreted Mucins
Current Organic Chemistry Non-Analgesic Effects of Opioids: Management of Opioid-Induced Constipation by Peripheral Opioid Receptor Antagonists: Prevention or Withdrawal?
Current Pharmaceutical Design Aging as an Epigenetic Phenomenon
Current Genomics Epidemiology and Management of Infectious Complications in Contemporary Management of Chronic Leukemias
Infectious Disorders - Drug Targets Chronopharmaceutics Based Modern Colon Specific Drug Delivery Systems
Current Drug Discovery Technologies Combination of DC Vaccine and Conventional Chemotherapeutics
Anti-Cancer Agents in Medicinal Chemistry Dietary Nitrite in Nitric Oxide Biology: A Redox Interplay with Implications for Pathophysiology and Therapeutics
Current Drug Targets Editorial (Thematic Issue: Revisiting the Revolution: Examining the Evolving Role of Antiangiogenic Therapy in Cancer)
Current Drug Targets The Gut Mucosa as a Site for Induction of Regulatory T-Cells
Current Pharmaceutical Design The Balancing Act between Colonisers and Inflammation: T regulatory and TH17 Cells in Mucosal Immunity during Otitis Media
Current Immunology Reviews (Discontinued) Ginkgolic Acids Confer Potential Anticancer Effects by Targeting Pro- Inflammatory and Oncogenic Signaling Molecules
Current Molecular Pharmacology Glutamate Carboxypeptidase II in Diagnosis and Treatment of Neurologic Disorders and Prostate Cancer
Current Medicinal Chemistry DNA Instability at Chromosomal Fragile Sites in Cancer
Current Genomics Diarylurea: A Privileged Scaffold in Drug Discovery and Therapeutic Development
Current Medicinal Chemistry