THERAPEUTIC REVOLUTION The History of Medical Oncology from Early Days to the Creation of the Subspecialty

Indexed in: EBSCO.

Cancer is a disease responsible for several million annual deaths among humans, worldwide. However, advances in healthcare - which include breakthroughs in science and medicine as well as access to ...
[view complete introduction]

US $
15

*(Excluding Mailing and Handling)



The Years of Creativity: 1953-1965. Pre-Clinical

Pp. 43-63 (21)

Pierre R. Band

Abstract

In 1953, the United States National Institutes, including the National Cancer Institute, were assembled in Bethesda. In 1955, a National Cancer Chemotherapy Program was established and scientific panels were formed with the participation of basic and clinical scientists and statisticians. An extensive experimental and clinical drug development program was initiated at the National Cancer Institute. Animal screening models predictive of anticancer drug activity were studied and criteria for preclinical toxicology and activity were developed. Important concepts emerged from experimental studies that influenced cancer therapy, including the dose-schedule and first-order kinetics principles, and the effects of anticancer agents on proliferating and resting cells. Under the leadership of Dr. Zubrod, the activities of a triumvirate of clinical scientists, Doctors Frei, Freireich and Holland, initially focussed on the treatment of acute leukemia, following up on Holland’s innovative use of a two-drug combination.

Keywords:

National Cancer Chemotherapy Program, screening, dose-schedule, first-order kinetics, cell-cycle specific, cell-cycle nonspecific, acute leukemia.

Affiliation:

Faculty of Medicine, McGill University, Montreal, Quebec H3G 1Y6, Canada.