THERAPEUTIC REVOLUTION The History of Medical Oncology from Early Days to the Creation of the Subspecialty

Indexed in: EBSCO.

Cancer is a disease responsible for several million annual deaths among humans, worldwide. However, advances in healthcare - which include breakthroughs in science and medicine as well as access to ...
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Combination Chemotherapy: The Road to Cure

Pp. 94-107 (14)

Pierre R. Band

Abstract

The principles of combination chemotherapy to overcome drug resistance and the use of high intermittent dosage to achieve maximal therapeutic benefits, first learned from studies in childhood acute lymphocytic leukemia, were applied to other hematologic malignancies and to solid tumors. As new drugs that were active against specific malignancies became available, they were tested in combination with other agents. Drugs with different mechanisms of action and no overlapping toxicity were preferentially selected for combination chemotherapy. Cures were achieved in Hodgkin’s disease, testicular cancer and Burkitt’s lymphoma, as well as improved survival in non-Hodgkin’s lymphomas. These major successes occurred in tumors characterized by a relatively rapid proliferating growth rates and were not paralleled by similar results in cancers with slower growth rates.

Keywords:

Combination chemotherapy, Hodgkin’s disease, non-Hodgkin’s lymphomas, Burkitt’s lymphoma, testicular cancer, tumor growth rate.

Affiliation:

Faculty of Medicine, McGill University, Montreal, Quebec H3G 1Y6, Canada.