The High Throughput Biomedicine (HTB) unit at the Institute for Molecular Medicine Finland
FIMM was established in 2010 to serve as a national and international academic screening unit providing
access to state of the art instrumentation for chemical and RNAi-based high throughput screening. The
initial focus of the unit was multiwell plate based chemical screening and high content microarray-based
siRNA screening. However, over the first four years of operation, the unit has moved to a more flexible
service platform where both chemical and siRNA screening is performed at different scales primarily in
multiwell plate-based assays with a wide range of readout possibilities with a focus on ultraminiaturization
to allow for affordable screening for the academic users. In addition to high throughput
screening, the equipment of the unit is also used to support miniaturized, multiplexed and high throughput
applications for other types of research such as genomics, sequencing and biobanking operations.
Importantly, with the translational research goals at FIMM, an increasing part of the operations at the
HTB unit is being focused on high throughput systems biological platforms for functional profiling of
patient cells in personalized and precision medicine projects.
Keywords: Chemical biology, high throughput screening, microarrays, miniaturization, personalized medicine, RNAi,
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