Abstract
In the past decade, academic screening centers have been created in many universities worldwide. Most of these screening centers are organized as core facilities that accept projects from both within their organization and from external users in order to maximize staff and instrument usage. The Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, Germany, also created such a screening facility named the Technology Development Studio (TDS). The mission of the facility is to provide cell based screening services focused on high resolution confocal imaging. The acquisition of high resolution images allows the mathematical description of cells with image analysis to a high degree of precision. This precision in turn allows classifying phenotypes accurately and compare different cellular treatments to discover underlying mechanisms.
Keywords: Chemical screening, complex biology, high content screening, multi parametric statistics, RNAi.
Combinatorial Chemistry & High Throughput Screening
Title:The Technology Development Studio of the MPI-CBG: An Open Access Cell-Based Screening Facility
Volume: 17 Issue: 4
Author(s): Marc Bickle
Affiliation:
Keywords: Chemical screening, complex biology, high content screening, multi parametric statistics, RNAi.
Abstract: In the past decade, academic screening centers have been created in many universities worldwide. Most of these screening centers are organized as core facilities that accept projects from both within their organization and from external users in order to maximize staff and instrument usage. The Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, Germany, also created such a screening facility named the Technology Development Studio (TDS). The mission of the facility is to provide cell based screening services focused on high resolution confocal imaging. The acquisition of high resolution images allows the mathematical description of cells with image analysis to a high degree of precision. This precision in turn allows classifying phenotypes accurately and compare different cellular treatments to discover underlying mechanisms.
Export Options
About this article
Cite this article as:
Bickle Marc, The Technology Development Studio of the MPI-CBG: An Open Access Cell-Based Screening Facility, Combinatorial Chemistry & High Throughput Screening 2014; 17 (4) . https://dx.doi.org/10.2174/1386207317666140323133018
DOI https://dx.doi.org/10.2174/1386207317666140323133018 |
Print ISSN 1386-2073 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5402 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Effect of Cholinergic Stimulation in Early Alzheimers Disease - Functional Imaging During a Recognition Memory Task
Current Alzheimer Research Determination of Epsilon Aminocaproic Acid Based on Charge Transfer Complexation with p-Nitrophenlol by Spectrophotometry
Current Pharmaceutical Analysis <i>In Silico</i> Study Examining New Phenylpropanoids Targets with Antidepressant Activity
Current Drug Targets Omega-3 Fatty Acids: Role in the Prevention and Treatment of Psychiatric Disorders
Current Psychiatry Reviews Hypotensive Agents from Snake Venoms
Current Drug Targets - Cardiovascular & Hematological Disorders Discovering New Treatments for Alzheimer's Disease by Repurposing Approved Medications
Current Topics in Medicinal Chemistry Treating Arterial Stiffness in Young and Elderly Patients with the Metabolic Syndrome
Current Pharmaceutical Design Past, Present and Future Therapeutics for Cerebellar Ataxias
Current Neuropharmacology Targeting Acetyl-CoA Carboxylases: Small Molecular Inhibitors and their Therapeutic Potential
Recent Patents on Anti-Cancer Drug Discovery Surrogates of Insulin Sensitivity and Indices of Cardiometabolic Profile in Obesity
Current Vascular Pharmacology Glycogen Synthase Kinase-3 in Neurodegeneration and Neuroprotection:Lessons from Lithium
Current Alzheimer Research Monitoring Molecular, Functional and Morphologic Aspects of Bone Metastases Using Non-Invasive Imaging
Current Pharmaceutical Biotechnology Psychological Stress and Puerperal Mastitis - Possible Pathophysiological Mechanisms
Current Women`s Health Reviews Development and Characterization of Novel Medicated Nanofibers Against Periodontitis
Current Drug Delivery Clinical Experiment of Mutant Herpes Simplex Virus HF10 Therapy for Cancer
Current Cancer Drug Targets Antifungal Agents in Hematopoietic Stem Cell Transplantation
Current Pharmaceutical Design Graphene and Graphene Oxide as Super Materials
Current Inorganic Chemistry (Discontinued) Paramutation: Just a Curiosity or Fine Tuning of Gene Expression in the Next Generation?
Current Genomics Oxidative Stress and the Pathogenesis of Atrial Fibrillation
Current Cardiology Reviews Chronic Kidney Disease, Metabolic Syndrome, and Cardiovascular Risk: Insights and Associated Mechanistic Pathways
Current Nutrition & Food Science