An Overview of Pharmacogenetics in Psychotropic Drugs

Author(s): Stephanie Ross, Zainab Samaan, Guillaume Pare

Journal Name: Current Psychiatry Reviews
Continued as Current Psychiatry Research and Reviews

Volume 10 , Issue 2 , 2014


There is considerable variation in the individualized response to psychotropic drug therapies, which include antidepressants, antipsychotics and mood stabilizers. It has been proposed that the wide interindividual variability in psychotropic drug-response may be attributable to genetic variants. Thus pharmacogenetics may help to accurately predict response to psychotropic treatment, and may be used as guidelines in selecting an appropriate psychotropic treatment in order to maximize drug efficacy and minimize drug toxicity. Although the clinical utility of psychiatric pharmacogenetics is very promising, its adoption in clinical practice has been slow. This resistance may stem from sometimes conflicting findings among pharmacogenetic studies. The failure to replicate these findings may result from a lack of high-quality studies and unresolved methodological issues. In this review we will address methodological and statistical challenges in pharmacogenetic studies and summarize the current pharmacogenetic literature on psychotropic drug-response.

Keywords: Antidepressants, antipsychotics, lithium, mood stabilizers, pharmacogenetics, risperidone, selective serotonin re-uptake inhibitors (SSRIs).

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Article Details

Year: 2014
Published on: 19 March, 2014
Page: [182 - 191]
Pages: 10
DOI: 10.2174/1573400510666140320000642
Price: $65

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