Synthesis and Biological Evaluation of Novel N' (4-aryloxybenzylidene)- 1H-Benzimidazole-2 Carbohydrazide Derivatives as Anti-Tubercular Agents

Author(s): Afsar Ali Siddiki, Vinod Kumar Bairwa, Vikas N. Telvekar

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 17 , Issue 7 , 2014

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Abstract:

A series of structurally novel, (E)-N'-(4-aryloxybenzylidene)-1H-benzimidazole-2-carbohydrazide derivatives were synthesized by molecular hybridization technique. All these compounds were evaluated against Mycobacterium tuberculosis H37Rv strains using Resazurin Microtiter assay (REMA) method. These compounds showed good antituberculosis activity with minimum inhibitory concentration (MIC) value of the range of 1.5-25 µg/mL.

Keywords: Anti-tubercular, benzimidazole, carbohydrazide esters, triclosan, molecular hybridization.

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Article Details

VOLUME: 17
ISSUE: 7
Year: 2014
Page: [630 - 638]
Pages: 9
DOI: 10.2174/1386207317666140314092412
Price: $65

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