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Combinatorial Chemistry & High Throughput Screening

Editor-in-Chief

ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

Synthesis and Biological Evaluation of Novel N' (4-aryloxybenzylidene)- 1H-Benzimidazole-2 Carbohydrazide Derivatives as Anti-Tubercular Agents

Author(s): Afsar Ali Siddiki, Vinod Kumar Bairwa and Vikas N. Telvekar

Volume 17, Issue 7, 2014

Page: [630 - 638] Pages: 9

DOI: 10.2174/1386207317666140314092412

Price: $65

Abstract

A series of structurally novel, (E)-N'-(4-aryloxybenzylidene)-1H-benzimidazole-2-carbohydrazide derivatives were synthesized by molecular hybridization technique. All these compounds were evaluated against Mycobacterium tuberculosis H37Rv strains using Resazurin Microtiter assay (REMA) method. These compounds showed good antituberculosis activity with minimum inhibitory concentration (MIC) value of the range of 1.5-25 µg/mL.

Keywords: Anti-tubercular, benzimidazole, carbohydrazide esters, triclosan, molecular hybridization.


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