Perifosine treatment exhibits a complex molecular response including the inhibition of Akt or the induction of apoptosis via
clustering of death receptors in lipid rafts. However, the molecular response can vary between different tumor entities and the
contribution of each target pathway to the activity of Perifosine might be distinct depending on the tumor entity or the agent combined
In this review we discuss the current view on the mechanism of action of perifosine in cancer and the contribution of the molecular
targets of Perifosine to its activity.