Synthesis and Pharmacological Screening of Novel 1,3-Disubstituted 5-Pyrazolones as Anticonvulsant Agents

Author(s): Basant Kumar Singh, Narsingh Sachan, Pooja Chawla

Journal Name: Current Bioactive Compounds

Volume 9 , Issue 4 , 2013

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Abstract:

Two series of novel 1-(4-substitutedbenzoyl)-3-((2-oxoimidazolin-1-yl)methyl)-1H-pyrazol-5(4H)-one, 1- methyl-3-((1-(4-substitutedbenzoyl)-5-oxo-4,5-dihydro-1H-pyrazol-3-yl)methyl)urea,1-((1-(4-substitutedbenzoyl)-5-oxo- 4,5-dihydro-1H-pyrazol-3-yl)methyl) thio urea and 1-((1-(4-substitutedbenzoyl)-5-oxo-4,5-dihydro-1H-pyrazol-3- yl)methyl)-3-phenyl thiourea were synthesized and characterized by IR, mass, 1HNMR spectroscopic techniques. The synthesized compounds were evaluated for anticonvulsant activity by using maximal electroshock seizure (MES) model. Among the newly synthesized compounds, most of the compounds showed significant activity and 1C2 emerged as the most active analogue.

Keywords: Anticonvulsant, convulsion, MES, pharmacophore, pyrazol-5-one.

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Article Details

VOLUME: 9
ISSUE: 4
Year: 2013
Page: [279 - 287]
Pages: 9
DOI: 10.2174/1573407210666140307011414
Price: $65

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