Due to the great prevalence of persistent and recurrent implanted device associated-infections novel and alternative
therapeutic approaches are intensely investigated. For reducing complications and antibiotic resistance development,
one major strategy is using natural or synthetic modulators for targeting microbial molecular pathways which are
not related with cell multiplication and death, as Quorum Sensing, virulence and biofilm formation. The purpose of this
review paper is to discuss the most recent in vitro approaches, investigating the efficiency of some novel antimicrobial
products and the nano-technologic progress performed in order to increase their effect and stability.
Keywords: Controlled release, implant-associated infections, nano-carriers, natural modulators, synthetic modulators, virulence.
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