Microbial biofilms are associated with drastically enhanced resistance to most of the antimicrobial agents and with frequent
treatment failures, generating the search for novel strategies which can eradicate infections by preventing the persistent colonization
of the hospital environment, medical devices or human tissues.
Some of the current approaches for fighting biofilms are represented by the development of novel biomaterials with increased
resistance to microbial colonization and by the improvement of the current therapeutic solutions with the aid of
This special issues includes papers describing the applications of nanotechnology and biomaterials science for the development
of improved drug delivery systems and nanostructured surfaces for the prevention and treatment of medical biofilms.
Nanomaterials display unique and well-defined physical and chemical properties making them useful for biomedical applications,
such as: very high surface area to volume ratio, biocompatibility, biodegradation, safety for human ingestion, capacity
to support surface modification and therefore, to be combined with other bioactive molecules or substrata and more importantly
being seemingly not attracting antimicrobial resistance.
The use of biomaterials is significantly contributing to the reduction of the excessive use of antibiotics, and consequently to
the decrease of the emergence rate of resistant microorganisms, as well as of the associated toxic effects. Various biomaterials
with intrinsic antimicrobial activity (inorganic nanoparticles, polymers, composites), medical devices for drug delivery, as well
as factors influencing their antimicrobial properties are presented.
One of the presented papers reviews the recent literature on the use of magnetic nanoparticles (MNP)-based nanomaterials
in antimicrobial applications for biomedicine, focusing on the growth inhibition and killing of bacteria and fungi, and, on viral
inactivation. The anti-pathogenic activity of the most common types of metallic/metal oxide nanoparticles, as well as the photocontrolled
targeted drug-delivery system and the development of traditional Chinese herbs nanoparticles are some of the highlights
of another paper of this issue.
The applications of synthetic, biodegradable polymers for the improvement of antiinfective therapeutic and prophylactic
agents (i.e., antimicrobial and anti-inflammatory agents and vaccines) activity, as well as for the design of biomaterials with
increased biocompatibility and resistance to microbial colonization are also discussed, as well as one of the most recent paradigms
of the pharmaceutical field and nanobiotechnology, represented by the design of smart multifunctional polymeric nanocarriers
for controlled drug delivery. These systems are responding to physico-chemical changes and as a result, they can release
the active substances in a controlled and targeted manner. The advantages and limitations of the main routes of polymerization
by which these nanovehicles are obtained, as well as the practical appllications in the field of drug nanocarriers are presented.
The authors describe the therapeutic applications of dendrimers, which are unimolecular, monodisperse nanocarriers
with unique branched tree-like globular structure.
The applications of nanotechnology for the stabilization and improved release of anti-pathogenic natural or synthetic compounds,
which do not interfere with the microbial growth, but inhibit different features of microbial pathogenicity are also highlighted.
We expect this special issue would offer a comprehensive update and give new directions for the design of micro/nano engineered
materials to inhibit microbial colonization on the surfaces or to potentiate the efficiency of the current/
novel/alternative antimicrobial agents by improving their bioavailability and pharmacokinetic features.