Pharmacology of Cyclic Peptides: Vancomycin and Oxytocin as Paradigms

Author(s): Johannes Schulze

Journal Name: Protein & Peptide Letters

Volume 21 , Issue 6 , 2014


Become EABM
Become Reviewer
Call for Editor

Abstract:

Cyclic oligopeptides have been introduced into pharmacological use for uses as diverse as selective release of the clotting factor VIII (von Willebrandt factor) by vasopressin, immune modulation by cyclosporin and antibacterial activity by vancomycin. Even now, 60 years after the first isolation of vancomycin (3,4) and the sequencing of oxytocin (48) these compounds have not lost their important role in clinical use. With regard to pharmacological properties oxytocin (as the peptide identic to the human sequence) and vancomycin (as a nonribosomal bacterial peptide) epitomize the swath of cyclic peptide properties.

Keywords: Cyclic peptides, discovery, oxytocin, vancomycin.

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 21
ISSUE: 6
Year: 2014
Published on: 24 April, 2014
Page: [593 - 596]
Pages: 4
DOI: 10.2174/0929866521666140221152226
Price: $65

Article Metrics

PDF: 25