Systems Biology: A New Tool for Farm Animal Science

Author(s): Kristin Hollung, Anna M. Timperio, Mamen Olivan, Caroline Kemp, Ana Coto-Montes, Veronica Sierra, Lello Zolla

Journal Name: Current Protein & Peptide Science

Volume 15 , Issue 2 , 2014

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It is rapidly emerging that the tender meat phenotype is affected by an enormous amount of variables, not only tied to genetics (livestock breeding selection), but also to extrinsic factors, such as feeding conditions, physical activity, rearing environment, administration of hormonal growth promotants, pre-slaughter handling and stress. Proteomics has been widely accepted by meat scientists over the last years and is now commonly used to shed light on the postmortem processes involved in meat tenderization. This review discusses the latest findings with the use of proteomics and systems biology to study the different biochemical pathways postmortem aiming at understanding the concerted action of different molecular mechanisms responsible for meat quality. The conversion of muscle to meat postmortem can be described as a sequence of events involving molecular pathways controlled by a complex interplay of many factors. Among the different pathways emerging are the influence of apoptosis and lately also the role of autophagy in muscle postmortem development. This review thus, focus on how systems-wide integrated investigations (metabolomics, transcriptomics, interactomics, phosphoproteomics, mathematical modeling), which have emerged as complementary tools to proteomics, have helped establishing a few milestones in our understanding of the events leading from muscle to meat conver

Keywords: Apoptosis, autophagy, farm animal, meat quality, system biology.

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Article Details

Year: 2014
Published on: 24 March, 2014
Page: [100 - 117]
Pages: 18
DOI: 10.2174/1389203715666140221120642
Price: $65

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