This paper reviews recent progress in salivary animal proteomics, with special reference to the porcine proteome.
Until fairly recently, most studies on saliva as a diagnostic fluid have focused on humans, primates and rodents, and the development
of salivary analysis in monitoring health in farm animals including pigs has received only limited consideration.
The porcine salivary proteome has been characterised by 2D-electrophoresis followed by mass spectrometry. Major and minor
proteins have been identified. The use of saliva as a non-invasive biological fluid in monitoring health and disease in pigs
will be reviewed, together with the potential use of proteomics for the development of biomarkers. In this review, methods of
collection and the composition of porcine saliva will be considered, together with saliva handling and analysis. The overall
findings indicate that there is considerable potential for the development of salivary analysis as a non-invasive diagnostic
fluid in the pig, and that it offers advantages over other body fluids in this animal.