Polyphenols contained in FGM from Negroamaro (N) and Koshu (K) Vitis vinifera have been shown to exhibit several immunomodulating
activities. For instance, mice affected by experimental colitis when administered with K-FGM showed an attenuation of
the inflammatory process. In murine asthma, K-FGM reduced IgE production and eosinophil number in bronchial alveolar lavage fluid.
In vitro, both N- and K-FGM were able to induce T regulatory cells in terms of Foxp-3 molecule expression and release of interleukin-10.
In another set of experiments both N- and K-FGM were able to balance rate of proliferation/apoptosis/necrosis of normal human peripheral
lymphocytes, thus indicating the property of these compounds to maintain immune homeostatic mechanisms in the host. On the other
hand, N- and K-FGM inhibited human basophil degranulation, thus, confirming our previous results obtained with rat basophilic leukemia
cells. Finally, N- and K-FGM also decreased oxidative burst of human polymorphonuclear cells and monocytes.Taken together,
these findings imply the potential clinical usefulness of FGM administration in inflammatory/allergic conditions, such as chronic asthma.