Abstract
In 2006, Takahashi and Yamanaka first established induced pluripotent stem cells (iPScs). Since then, numerous improvements have been made in the fields of stem cell research, drug research, modelling of diseases, and the treatment of degenerative diseases. Recently, there has been increasing research involving small molecules for evaluating the efficiency of iPSc generation and reducing the risks of heredity as well as oncogenous problems. However, the molecular mechanisms of iPScs remain to be further explored, to meet the demands of practical applications. With a better understanding of degenerative diseases, more complex treatment strategies for novel regenerative medicine are anticipated, and iPSc technology offers an available pathway. This review focuses on the development and application of iPScs.
Keywords: Application, degenerative disease, differentiation, epigenetic regulation, induced pluripotent stem cells, regenerative medicine.
Current Stem Cell Research & Therapy
Title:Development Course and an Application Strategy for Induced Pluripotent Stem Cells in Regenerative Medicine
Volume: 9 Issue: 3
Author(s): Yuanzhi Xu, Jing Wang, Runyi Mao, Xiaoshan Tang, Renhuan Huang, Raorao Wang and Yunfeng Lin
Affiliation:
Keywords: Application, degenerative disease, differentiation, epigenetic regulation, induced pluripotent stem cells, regenerative medicine.
Abstract: In 2006, Takahashi and Yamanaka first established induced pluripotent stem cells (iPScs). Since then, numerous improvements have been made in the fields of stem cell research, drug research, modelling of diseases, and the treatment of degenerative diseases. Recently, there has been increasing research involving small molecules for evaluating the efficiency of iPSc generation and reducing the risks of heredity as well as oncogenous problems. However, the molecular mechanisms of iPScs remain to be further explored, to meet the demands of practical applications. With a better understanding of degenerative diseases, more complex treatment strategies for novel regenerative medicine are anticipated, and iPSc technology offers an available pathway. This review focuses on the development and application of iPScs.
Export Options
About this article
Cite this article as:
Xu Yuanzhi, Wang Jing, Mao Runyi, Tang Xiaoshan, Huang Renhuan, Wang Raorao and Lin Yunfeng, Development Course and an Application Strategy for Induced Pluripotent Stem Cells in Regenerative Medicine, Current Stem Cell Research & Therapy 2014; 9 (3) . https://dx.doi.org/10.2174/1574888X09666140213202227
DOI https://dx.doi.org/10.2174/1574888X09666140213202227 |
Print ISSN 1574-888X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3946 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Cardiovascular Imaging in Thromboembolic Risk Stratification for Atrial Fibrillation: Recent Patents and Current Practice
Recent Patents on Medical Imaging New Approaches for the Treatment of Chagas Disease
Current Drug Targets Problems in Stem Cell Therapy for Cardiac Repair and Tissue Engineering Approaches Based on Graphene and Its Derivatives
Current Stem Cell Research & Therapy Reactive Oxygen Species in Myocardial Reperfusion Injury: From Physiopathology to Therapeutic Approaches
Current Pharmaceutical Biotechnology Chromogranin-A: A Multifaceted Cardiovascular Role in Health and Disease
Current Medicinal Chemistry Antipsychotic-Induced Electrocardiographic Changes: A Comparative Study Between Olanzapine and Risperidone
Current Psychopharmacology New Chemotherapeutic Strategies Against Malaria, Leishmaniasis and Trypanosomiases
Current Medicinal Chemistry Non-Analgesic Effects of Opioids: Interactions Between Opioids and Other Drugs
Current Pharmaceutical Design Application of Proteomics in Cardiovascular Research
Current Proteomics Potential Roles of MyomiRs in Cardiac Development and Related Diseases
Current Cardiology Reviews Facilitated/Pharmaco-invasive Approaches in STEMI
Current Cardiology Reviews Natriuretic Peptide Guided Heart Failure Management
Current Clinical Pharmacology Perspectives on Medicinal Properties of Benzoquinone Compounds
Mini-Reviews in Medicinal Chemistry Subject Index To Volume 2
Current Cardiology Reviews Sudden Unexplained Death in Infancy and Long QT Syndrome
Current Pediatric Reviews The Spatial QRS-T Angle: Implications in Clinical Practice
Current Cardiology Reviews Targeting Ion Channels in Leukemias: A New Challenge for Treatment
Current Medicinal Chemistry Discovery of Aroyl Piperazine Derivatives as I<sub>Kr</sub> & I<sub>Ks</sub> Dual Inhibitors for Cardiac Arrhythmia Treatment
Medicinal Chemistry Hypertension in 2017: Update in Treatment and Pharmaceutical Innovations
Current Pharmaceutical Design BK Channel Modulators: A Comprehensive Overview
Current Medicinal Chemistry