The Endothelial-Mesenchymal Transition (EndMT) and Tissue Regeneration

Author(s): Wenjing Yu, Zhen Liu, Shu An, Jinyi Zhao, Lan Xiao, Yongchao Gou, Yunfeng Lin, Jun Wang

Journal Name: Current Stem Cell Research & Therapy

Volume 9 , Issue 3 , 2014

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Recent studies have brought endothelial-mesenchymal transition (EndMT) as a special perspective of epithelial- mesenchymal transition (EMT) into eyes. Traditionally, EndMT is considered as a source for fibroblasts and myofibroblasts, and it is extensively investigated in physiologic cardiac development as well as in pathologic tumor and fibrosis. Recently, new studies have found that EndMT-transformed cells had ‘stemness’, which means they could differentiate into chondroblasts, osteoblasts, and adipoblasts in differential culture, respectively. This gives EndMT a bright application future in tissue engineering and regeneration, especially for the formation of cartilage and bone.

Keywords: Endothelial-mesenchymal transition (EndMT), endothelial cells, mesenchymal stem cells (MSCs), EndMTtransformed cells, tissue regeneration, transforming growth factor-β (TGF-β).

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Article Details

Year: 2014
Page: [196 - 204]
Pages: 9
DOI: 10.2174/1574888X09666140213154144
Price: $65

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PDF: 157