Mechanisms of Vascular Calcification and Associated Diseases

Author(s): Juliana Marulanda, Saleh Alqarni, Monzur Murshed

Journal Name: Current Pharmaceutical Design

Volume 20 , Issue 37 , 2014

Become EABM
Become Reviewer

Abstract:

Mineralization of bone and tooth extracellular matrix (ECM) is a physiologic process, while soft tissue mineralization, also known as ectopic mineralization (calcification), is a pathologic condition. Vascular calcification is common in aging and also in a number of genetic and metabolic disorders. The calcific deposits in arteries complicate the prognosis and increase the morbidity in diseases such as atherosclerosis, diabetes and chronic kidney disease (CKD). To completely understand the pathophysiology of these lifethreatening diseases, it is critical to elucidate the molecular mechanisms underlying vascular calcification. Unveiling these mechanisms will eventually identify new therapeutic targets and also improve the management of the associated complications. In the current review, we discussed the common determinants of ECM mineralization, the mechanism of vascular calcification associated with several human diseases and outlined the most common therapeutic approaches to prevent its progression.

Keywords: Extracellular matrix mineralization, vascular calcification, mineralization inhibitors, animal models.

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 20
ISSUE: 37
Year: 2014
Page: [5801 - 5810]
Pages: 10
DOI: 10.2174/1381612820666140212205848
Price: $65

Article Metrics

PDF: 50