Abstract
Traditionally abdominal aortic calcification (AAC) has received less intensive study than coronary artery calcification. The widespread use of abdominal imaging has however encouraged recent investigation of this problem. Human association studies suggest that older age, chronic kidney disease and osteoporosis are the most important risk factors for AAC. AAC severity has been consistently associated with death and cardiovascular events and therefore there is growing interest in identifying potential therapies to limit AAC. At present there have only been a small number of well controlled trials designed to assess effective interventions for AAC. Further studies are expected over the coming years. Whether an intervention which effectively limits AAC will also reduce the incidence of cardiovascular events remains to be established.
Keywords: Aorta, calcification, abdominal aortic calcification, cardiovascular events.
Current Pharmaceutical Design
Title:Abdominal Aortic Calcification: Clinical Significance, Mechanisms and Therapies
Volume: 20 Issue: 37
Author(s): Jonathan Golledge
Affiliation:
Keywords: Aorta, calcification, abdominal aortic calcification, cardiovascular events.
Abstract: Traditionally abdominal aortic calcification (AAC) has received less intensive study than coronary artery calcification. The widespread use of abdominal imaging has however encouraged recent investigation of this problem. Human association studies suggest that older age, chronic kidney disease and osteoporosis are the most important risk factors for AAC. AAC severity has been consistently associated with death and cardiovascular events and therefore there is growing interest in identifying potential therapies to limit AAC. At present there have only been a small number of well controlled trials designed to assess effective interventions for AAC. Further studies are expected over the coming years. Whether an intervention which effectively limits AAC will also reduce the incidence of cardiovascular events remains to be established.
Export Options
About this article
Cite this article as:
Golledge Jonathan, Abdominal Aortic Calcification: Clinical Significance, Mechanisms and Therapies, Current Pharmaceutical Design 2014; 20 (37) . https://dx.doi.org/10.2174/1381612820666140212195309
DOI https://dx.doi.org/10.2174/1381612820666140212195309 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Pharmacotherapies to Manage Bone Loss-Associated Diseases: A Quest for the Perfect Benefit-to-Risk Ratio
Current Medicinal Chemistry Cardiac Toxicities of Antiangiogenic Therapies
Current Angiogenesis (Discontinued) Targeting the Human Thioredoxin System by Diverse Strategies to Treat Cancer and Other Pathologies
Recent Patents on DNA & Gene Sequences Glucans as Biological Response Modifiers
Endocrine, Metabolic & Immune Disorders - Drug Targets MicroRNAs Determining Inflammation as Novel Biomarkers and Potential Therapeutic Targets
Current Medicinal Chemistry Central Nervous System Agents Used as Trypanosoma cruzi Infection Chemotherapy: Phenothiazines and Related Compounds
Current Medicinal Chemistry - Anti-Infective Agents Dynamics of Telomere Length in Different Age Groups in a Latvian Population
Current Aging Science Recent Advances in Hematopoietic Stem Cell-Mediated Regeneration
Recent Patents on Regenerative Medicine Obesity, Metabolic Syndrome, Diabetes and Arterial Hypertension
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Antibody-Mediated Endothelial Cell Damage Via Nitric Oxide
Current Pharmaceutical Design Role and Services of a Pharmacist in the Prevention of Medication Errors: A Systematic Review
Current Drug Safety Impact of Polypharmacy on Adherence to Evidence-Based Medication in Patients who Underwent Percutaneous Coronary Intervention
Current Vascular Pharmacology A<sub>3</sub> Adenosine Receptor: A Plausible Therapeutic Target for Cardio-Protection in Diabetes
Recent Patents on Cardiovascular Drug Discovery Managing Comorbidity in COPD: A Difficult Task
Current Drug Targets Virtual Screening for Cholesterol Absorption Inhibitors
Medicinal Chemistry Immunophilins and Cardiovascular Complications
Current Medicinal Chemistry NGS of microRNAs Involved in Cardioprotection Induced by Sevoflurane Compared to Propofol in Myocardial Revascularization Surgery: The ACDHUVV-16 Clinical Trial
Current Medicinal Chemistry What We Learnt from Randomized Clinical Trials and Cohort Studies of Antioxidant Vitamin? : Focus on Vitamin E and Cardiovascular Disease
Current Pharmaceutical Biotechnology The Role of Uric Acid and Methyl Derivatives in the Prevention of Age-Related Neurodegenerative Disorders
Current Topics in Medicinal Chemistry Monitoring and Surveillance of Obesity in the United States
Current Nutrition & Food Science