The present article highlights diverse roles of stem cells in healthy state, oncology and regenerative medicine in
comparison to the Clear Cell Renal Cell Carcinoma (ccRCC) “stem cells”. Furthermore, we support the notion of urgent
need to change the terminology of “cancer stem cells” into tumor-propagating cells (TPCs), and to diversify terms of
kidney stem and kidney progenitor cell. We present the role of normal stem and progenitor cells in kidney development
and regeneration in comparison to their markers. Moreover, we would like to introduce a hypothesis about the TPCs
origin, and the role epithelial to mesenchymal transition in metastasis. We described current knowledge about various
approaches to identification of renal TPCs. Finally, we present future perspectives in respect to current studies.
Keywords: Cancer stem cells, ccRCC, stem cells, tumor-propagating cells.
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