Abstract
An efficient preparation of the girgensohnine and its close analogs with α-aminonitrile structure, and their spectral characterization were reported for the first time. The piperidine α-aminonitriles were obtained through 5 mol% InCl3-catalyzed one-pot Strecker reaction, and tested for antioxidant activity and AChE inhibitory properties. It was found that girgensohnine possesses a moderate AChE inhibitory property while its spiroanalog shows good antioxidant capacity.
Keywords: AChE inhibitory activity, alkaloids, α-Aminonitriles, antioxidant capacity, girgensohnine, Strecker reaction.
Current Organic Synthesis
Title:First Girgensohnine Analogs Prepared Through InCl3-catalyzed Strecker Reaction and their Bioprospection
Volume: 10 Issue: 6
Author(s): Leonor Y. Vargas Mendez and Vladimir V. Kouznetsov
Affiliation:
Keywords: AChE inhibitory activity, alkaloids, α-Aminonitriles, antioxidant capacity, girgensohnine, Strecker reaction.
Abstract: An efficient preparation of the girgensohnine and its close analogs with α-aminonitrile structure, and their spectral characterization were reported for the first time. The piperidine α-aminonitriles were obtained through 5 mol% InCl3-catalyzed one-pot Strecker reaction, and tested for antioxidant activity and AChE inhibitory properties. It was found that girgensohnine possesses a moderate AChE inhibitory property while its spiroanalog shows good antioxidant capacity.
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Cite this article as:
Mendez Y. Vargas Leonor and Kouznetsov V. Vladimir, First Girgensohnine Analogs Prepared Through InCl3-catalyzed Strecker Reaction and their Bioprospection, Current Organic Synthesis 2013; 10 (6) . https://dx.doi.org/10.2174/157017941006140206105449
DOI https://dx.doi.org/10.2174/157017941006140206105449 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
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