Trifluoromethylated Heterocycles

Author(s): Andrei A. Gakh, Yuriy Shermolovich.

Journal Name: Current Topics in Medicinal Chemistry

Volume 14 , Issue 7 , 2014

Become EABM
Become Reviewer

Graphical Abstract:


This review is a follow-up to the previous chapter, “Monofluorinated Heterocycles” (Topics in Heterocyclic Chemistry, 2012, 33–63), and presents an overview of synthetic chemistry of heterocycles with only one trifluoromethyl group directly attached to the ring (trifluoromethylated heterocycles). Particular attention is given to the modern direct trifluoromethylation methods, including catalytic reactions, organometallic reagents, carbene and hypervalent chemistry, utilization of ionic nucleophilic and electrophilic trifluoromethylating agents, and to other pertinent trends. One of the emphases of the review is compounds with biomedical potential.

Keywords: Trifluoromethyl group, heterocycles.

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2014
Page: [952 - 965]
Pages: 14
DOI: 10.2174/1568026614666140202210424
Price: $65

Article Metrics

PDF: 37