Abstract
All domains of society are impacted by fluorine chemistry. In particular, fluorine plays a key role in medicinal, pharmaceutical and agrochemical sciences in which the synthesis and evaluation of molecules featuring one or more fluorine atoms is nowadays routine in every new discovery and development program. Since the beginning of this century, enantiopure fluorinated molecules are at the forefront of innovation of the tremendous achievements in fluorine chemistry. This review introduces the reader to the recent progress in asymmetric installation of one fluorine and a trifluoromethyl group via nucleophilic, electrophilic and radical diastereo- and enantioselective reactions.
Keywords: Fluorine, fluorination, trifluoromethylation, chirality, asymmetric synthesis.
Current Topics in Medicinal Chemistry
Title:Recent Progress in Asymmetric Fluorination and Trifluoromethylation Reactions
Volume: 14 Issue: 7
Author(s): Vincent Bizet, Tatiana Besset, Jun-An Ma and Dominique Cahard
Affiliation:
Keywords: Fluorine, fluorination, trifluoromethylation, chirality, asymmetric synthesis.
Abstract: All domains of society are impacted by fluorine chemistry. In particular, fluorine plays a key role in medicinal, pharmaceutical and agrochemical sciences in which the synthesis and evaluation of molecules featuring one or more fluorine atoms is nowadays routine in every new discovery and development program. Since the beginning of this century, enantiopure fluorinated molecules are at the forefront of innovation of the tremendous achievements in fluorine chemistry. This review introduces the reader to the recent progress in asymmetric installation of one fluorine and a trifluoromethyl group via nucleophilic, electrophilic and radical diastereo- and enantioselective reactions.
Export Options
About this article
Cite this article as:
Bizet Vincent, Besset Tatiana, Ma Jun-An and Cahard Dominique, Recent Progress in Asymmetric Fluorination and Trifluoromethylation Reactions, Current Topics in Medicinal Chemistry 2014; 14 (7) . https://dx.doi.org/10.2174/1568026614666140202205531
DOI https://dx.doi.org/10.2174/1568026614666140202205531 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
Call for Papers in Thematic Issues
Chemistry Based on Natural Products for Therapeutic Purposes
The development of new pharmaceuticals for a wide range of medical conditions has long relied on the identification of promising natural products (NPs). There are over sixty percent of cancer, infectious illness, and CNS disease medications that include an NP pharmacophore, according to the Food and Drug Administration. Since NP ...read more
Current Trends in Drug Discovery Based on Artificial Intelligence and Computer-Aided Drug Design
Drug development discovery has faced several challenges over the years. In fact, the evolution of classical approaches to modern methods using computational methods, or Computer-Aided Drug Design (CADD), has shown promising and essential results in any drug discovery campaign. Among these methods, molecular docking is one of the most notable ...read more
Drug Discovery in the Age of Artificial Intelligence
In the age of artificial intelligence (AI), we have witnessed a significant boom in AI techniques for drug discovery. AI techniques are increasingly integrated and accelerating the drug discovery process. These developments have not only attracted the attention of academia and industry but also raised important questions regarding the selection ...read more
From Biodiversity to Chemical Diversity: Focus of Flavonoids
Flavonoids are the largest group of polyphenols, plant secondary metabolites arising from the essential aromatic amino acid phenylalanine (or more rarely from tyrosine) via the phenylpropanoid pathway. The flavan nucleus is the basic 15-carbon skeleton of flavonoids (C6-C3-C6), which consists of two phenyl rings (A and B) and a heterocyclic ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Dendrimers and Dendritic Polymers as Anti-infective Agents: New Antimicrobial Strategies for Therapeutic Drugs
Anti-Infective Agents in Medicinal Chemistry <i>In Silico</i> Modeling of COVID-19 Pandemic Course Differentiation Using the FOD Model
Coronaviruses COVID-19 Pandemic: Current Scenario, Challenges and Future Perspectives
Coronaviruses Novel Nicotinonitrile Derivatives Bearing Imino Moieties Enhance Apoptosis and Inhibit Tyrosine Kinase
Anti-Cancer Agents in Medicinal Chemistry Molecular Topology and Other Promiscuity Determinants as Predictors of Therapeutic Class - A Theoretical Framework to Guide Drug Repositioning?
Current Topics in Medicinal Chemistry p53-Induced Apoptosis and Inhibitors of p53
Current Medicinal Chemistry Disruption of Circadian Rhythms in Critical Illness - A Role of Hyperoxia-Induced Lung Injury
Current Pharmaceutical Design Ca<sup>2+</sup>/cAMP Ratio as an Inflammatory Index
Current Hypertension Reviews Medicinal Chemistry of 5-HT5A Receptor Ligands: A Receptor Subtype with Unique Therapeutical Potential
Current Topics in Medicinal Chemistry EBV Reactivation in A Case of DRESS Syndrome Associated with Lamotrigine: A Case Report
New Emirates Medical Journal Artificial Intelligence Approaches for Rational Drug Design and Discovery
Current Pharmaceutical Design New Prospects for Drug Discovery from Structural Studies of Rhodopsin
Current Pharmaceutical Design Early Life Vitamin D Status and Lung Development
Current Respiratory Medicine Reviews New Strategies for Necrotizing Enterocolitis Diagnosis and Prevention in Newborns
Current Pediatric Reviews Targeting Steroid Hormone Receptor Pathways in the Treatment of Hormone Dependent Cancers
Current Pharmaceutical Biotechnology Synthesis, Structure-Activity Relationship and Biological Activity of Acridine Derivatives as Potent MDR-Reversing Agents
Current Medicinal Chemistry Motivations of older Chinese adult learners in Hong Kong
Current Aging Science New Therapeutic Frontiers for Metabotropic Glutamate Receptors
Current Topics in Medicinal Chemistry An Update on Promising Agents against COVID-19: Secondary Metabolites and Mechanistic Aspects
Current Pharmaceutical Design A New Nucleotide-composition Based Fingerprint of SARS-CoV with Visualization Analysis
Medicinal Chemistry