Biologically Active Synthetic Anionophores

Author(s): Andreea R. Schmitzer, Claude-Rosny Elie, Marc Vidal, Mathieu Charbonneau, Audrey Hebert

Journal Name: Current Organic Chemistry

Volume 18 , Issue 11 , 2014

Become EABM
Become Reviewer
Call for Editor

Graphical Abstract:


The physiological importance of proteins that can regulate ion balance and transmembrane transport is highlighted by different diseases where ion channel dysfunction is observed. During the past two decades, considerable effort has been devoted to develop synthetic ionophores that can insert or cross cell membranes and restore the dysfunction of highly complex protein channels.

Not withstanding the remarkable structural advances made, only a few classes of synthetic ionophores were studied in complex with proand eukaryote cells in order to obtain information about their biological activity and potential application in ion channel replacement therapy, anti-cancer therapy or antimicrobial treatments. However, only a few synthetic ionophores showed promising biological activity in cellular assays. This review aims to show the utility of synthetic ionophores for different biological applications, including: restoring ion concentration, inducing cell death in different cancer cells, and protecting against a variety of pathogenic microbes. Because the activities of these ionophores depend primarily on their overall physicochemical properties and structure, we discuss here specific functional units and scaffolds that are important for obtaining selective, non-toxic transporters for specific biological applications.

Keywords: Anionophores, anion transporters, biological applications.

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2014
Published on: 14 August, 2014
Page: [1482 - 1490]
Pages: 9
DOI: 10.2174/1385272819666140201002503
Price: $58

Article Metrics

PDF: 15