Synthesis and Anti-Cancer Activities of Aryl Benzyl Ethers with Fluoro Substituents

Yi  Jiang,  Hong  Xu,  Li  Liu,  Rui  He,  Xiaomei  Song and   Na  Li

Synthesis and Anti-Cancer Activities of Aryl Benzyl Ethers with Fluoro Substituents

Author(s): Yi Jiang, Hong Xu, Li Liu, Rui He, Xiaomei Song, Na Li

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Journal Name: Letters in Drug Design & Discovery

Volume 11 , Issue 6 , 2014

DOI : 10.2174/1570180811666140130232233

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A series of aryl benzyl ethers with fluoro substituents were synthesized and their structures were confirmed by spectral. All the compounds were tested for their cytotoxic activity in vitro against two human tumor cell lines: A549, SGC7901, and most showed cytotoxicity. Compound 10 was the most active in suppressing the growth of both screened cancer cells.

Keywords: Cancer, Drug design, Anti-cancer activity, Aryl benzyl ethers, Fluoro substituents, Structure-activity relationship.

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Letters in Drug Design & Discovery

Title:Synthesis and Anti-Cancer Activities of Aryl Benzyl Ethers with Fluoro Substituents

VOLUME: 11 ISSUE: 6

Author(s):Yi Jiang, Hong Xu, Li Liu, Rui He, Xiaomei Song and Na Li

Affiliation:Shaanxi university of Chinese medicine, shijidadao, xianyang, 712046, China.

Keywords:Cancer, Drug design, Anti-cancer activity, Aryl benzyl ethers, Fluoro substituents, Structure-activity relationship.

Abstract:A series of aryl benzyl ethers with fluoro substituents were synthesized and their structures were confirmed by spectral. All the compounds were tested for their cytotoxic activity in vitro against two human tumor cell lines: A549, SGC7901, and most showed cytotoxicity. Compound 10 was the most active in suppressing the growth of both screened cancer cells.

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Yi Jiang, Hong Xu, Li Liu, Rui He, Xiaomei Song and Na Li, “Synthesis and Anti-Cancer Activities of Aryl Benzyl Ethers with Fluoro Substituents”, Letters in Drug Design & Discovery (2014) 11: 736. https://doi.org/10.2174/1570180811666140130232233

DOI https://doi.org/10.2174/1570180811666140130232233	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X

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Article Details

VOLUME: 11
ISSUE: 6
Year: 2014

Published on: 28 May, 2014

Page: [736 - 741]
Pages: 6
DOI: 10.2174/1570180811666140130232233
Price: $65

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