Stereoselective Synthesis and Application of β-Amino Ketones

Author(s): Nghi H. Nguyen, Andrew B. Hughes, Brad E. Sleebs

Journal Name: Current Organic Chemistry

Volume 18 , Issue 2 , 2014

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β-Amino ketones are of increasing interest owing to their utility as important synthetic precursors in the synthesis of bioactive molecules and natural products. As a result numerous syntheses of β-amino ketones have emerged in recent years. Of particular significance are those methods that allow access to stereopure β-amino ketones. This review highlights recent advances in stereoselective syntheses of β-amino ketones and also illustrates the importance of β-amino ketones as useful synthons.

Keywords: β-amino ketones, amino alcohols, conjugate additions, diastereoselectivity, enantioselectivity, Mannich addition.

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Article Details

Year: 2014
Page: [260 - 289]
Pages: 30
DOI: 10.2174/138527281802140129104218
Price: $58

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