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Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Stereoselective Synthesis and Application of β-Amino Ketones

Author(s): Nghi H. Nguyen, Andrew B. Hughes and Brad E. Sleebs

Volume 18, Issue 2, 2014

Page: [260 - 289] Pages: 30

DOI: 10.2174/138527281802140129104218

Price: $65

Abstract

β-Amino ketones are of increasing interest owing to their utility as important synthetic precursors in the synthesis of bioactive molecules and natural products. As a result numerous syntheses of β-amino ketones have emerged in recent years. Of particular significance are those methods that allow access to stereopure β-amino ketones. This review highlights recent advances in stereoselective syntheses of β-amino ketones and also illustrates the importance of β-amino ketones as useful synthons.

Keywords: β-amino ketones, amino alcohols, conjugate additions, diastereoselectivity, enantioselectivity, Mannich addition.


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