Abstract
The low molecular weight GTP-binding protein RhoA regulates many cellular events, including cell migration, organization of the cytoskeleton, cell adhesion, progress through the cell cycle and gene expression. Physical forces influence these cellular processes in part by regulating RhoA activity through mechanotransduction of cell adhesion molecules (e.g. integrins, cadherins, Ig superfamily molecules). RhoA activity is regulated by guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs) that are themselves regulated by many different signaling pathways. Significantly, the engagement of many cell adhesion molecules can affect RhoA activity in both positive and negative ways. In this brief review, we consider how RhoA activity is regulated downstream from cell adhesion molecules and mechanical force. Finally, we highlight the importance of mechanotransduction signaling to RhoA in normal cell biology as well as in certain pathological states.
Keywords: Actin, adhesion, cytoskeleton, GTPase, force, mechanotransduction, RhoA.
Current Molecular Medicine
Title:Regulation of RhoA Activity by Adhesion Molecules and Mechanotransduction
Volume: 14 Issue: 2
Author(s): R.J. Marjoram, E.C. Lessey and K. Burridge
Affiliation:
Keywords: Actin, adhesion, cytoskeleton, GTPase, force, mechanotransduction, RhoA.
Abstract: The low molecular weight GTP-binding protein RhoA regulates many cellular events, including cell migration, organization of the cytoskeleton, cell adhesion, progress through the cell cycle and gene expression. Physical forces influence these cellular processes in part by regulating RhoA activity through mechanotransduction of cell adhesion molecules (e.g. integrins, cadherins, Ig superfamily molecules). RhoA activity is regulated by guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs) that are themselves regulated by many different signaling pathways. Significantly, the engagement of many cell adhesion molecules can affect RhoA activity in both positive and negative ways. In this brief review, we consider how RhoA activity is regulated downstream from cell adhesion molecules and mechanical force. Finally, we highlight the importance of mechanotransduction signaling to RhoA in normal cell biology as well as in certain pathological states.
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Cite this article as:
Marjoram R.J., Lessey E.C. and Burridge K., Regulation of RhoA Activity by Adhesion Molecules and Mechanotransduction, Current Molecular Medicine 2014; 14 (2) . https://dx.doi.org/10.2174/1566524014666140128104541
DOI https://dx.doi.org/10.2174/1566524014666140128104541 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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