A Sustainable Approach to Bis-Indole Synthesis Using Propylene Carbonate as an Eco-Friendly Solvent

Author(s): Priscila N. de Azevedo, Leina S. Behenck, Josue S. Bello Forero, July A. Hernandez Munoz, Erika M. de Cavalho, Joel Jones Junior, e Flavia M. da Silva

Journal Name: Current Organic Synthesis

Volume 11 , Issue 4 , 2014

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Graphical Abstract:


We prepared a series of bis-indole derivatives from different aldehydes and/or substituted isatins using molecular iodine as a catalyst and propylene carbonate as a “green” solvent. Simply stirring the components at room temperature produced high yield compound synthesis with a methodology that is clean, economical and efficient.

Keywords: Green chemistry, heterocycle, indole, iodine, isatin, propylene carbonate.

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Article Details

Year: 2014
Published on: 28 July, 2014
Page: [605 - 611]
Pages: 7
DOI: 10.2174/1570179411666140115225758
Price: $65

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