Title:A Sustainable Approach to Bis-Indole Synthesis Using Propylene Carbonate as an Eco-Friendly Solvent
VOLUME: 11 ISSUE: 4
Author(s):Priscila N. de Azevedo, Leina S. Behenck, Josue S. Bello Forero, July A. Hernandez Munoz, Erika M. de Cavalho, Joel Jones Junior and e Flavia M. da Silva
Affiliation:Sintese Orgânica Ambiental - IQ/UFRJ, caixa postal: 68.584, CEP 21941-972 - Rio de Janeiro, RJ, Brasil.
Keywords:Green chemistry, heterocycle, indole, iodine, isatin, propylene carbonate.
Abstract:We prepared a series of bis-indole derivatives from different aldehydes and/or substituted isatins using molecular iodine as a
catalyst and propylene carbonate as a “green” solvent. Simply stirring the components at room temperature produced high yield compound
synthesis with a methodology that is clean, economical and efficient.
